Suppression of Strychnine on the Chronotropic and Inotropic Effects in the Isolated, Blood-Perfused Canine Atrium

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Suppression of strychnine on the chronotropic and inotropic effects in the isolated, blood-perfused canine atrium.

In the isolated, blood-perfused dog atrium, strychnine evoked dose-dependent decreases in atrial rate and contractile force, and the negative cardiac effects were not influenced by atropine. Strychnine suppressed dose-dependently the negative chronotropic and inotropic responses to intramural parasympathetic nerve stimulation, but not the response to acetylcholine. These results suggest that st...

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ژورنال

عنوان ژورنال: Japanese Journal of Pharmacology

سال: 1985

ISSN: 0021-5198

DOI: 10.1254/jjp.38.439